The only issue i encoutered was adding a reference to 'Microsoft.CSharp'
using System; using System.Windows; using System.Windows.Controls; using Microsoft.Scripting.Silverlight; /// /// script.py => def Adder (x, y) : return x + y /// namespace DLRSilverlight { public partial class MainPage : UserControl { dynamic runtime = DynamicEngine.CreateRuntime().UseFile("script.py"); public MainPage() { InitializeComponent(); } private void button1_Click(object sender, RoutedEventArgs e) { dynamic result = runtime.Adder(Convert.ToDouble(this.N1.Text), Convert.ToDouble(this.N2.Text)); MessageBox.Show(String.Format("{0}", result)); } } }